The pepperoni roll is an Italian-American stuffed bread roll. Originally conceived of as a coal miner's lunch, it is popular in West Virginia and some nearby regions of the Appalachian Mountains such as Eastern Kentucky, Western Pennsylvania, Western Maryland, and Appalachian Ohio. In West Virginia it is nearly ubiquitous, particularly in convenience stores, and is arguably the food most closely associated with the state. Pepperoni rolls are also found in Southeast Michigan where they were popular among auto workers in the factories.

The classic pepperoni roll consists of a fairly soft white yeast-leavened bread roll with pepperoni baked in the middle. During baking, the fats in the pepperoni (which are hard at room temperature) melt, resulting in a spicy oil suffusing into the bread. Pepperoni rolls are typically eaten for lunch or breakfast, either unheated or slightly warmed.